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To confirm that tree-based ML models are the most appropriate for our analysis we also built Least Absolute Shrinkage and Selection Operator (LASSO) models to predict circulating TMAO in the left-out group using again fivefold cross-validation with all the available variables (full model) as input in BMIS ( N = 582

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Indeed, miR-155 has long been recognized as a key player in inflammatory responses, particularly in conditions of oxidative stress [32]

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sub-phenotype-3 (23.4%) with skeleto-muscular and nervous disorders