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Subsequent analysis identified enriched shRNAs corresponding to genes whose downregulation promoted survival of ATP7B-KO cells upon Cu overload (Fig

Mitochondrial dysfunction and longevity in animals: untangling the knot

After detailed characterization the novel roGFP2-iL probe was thus used to determine E GSH in the cytosol of rml1 seedlings in order to define the lower limit of glutathione redox potentials under which viability can be maintained

Interestingly, this change mainly resulted from the increased sensitivity to meropenem rather than GSH activity