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To conclude, both ferroptosis and pyroptosis are important pathophysiological mechanisms

Ischemia also triggers the depolarization of the mitochondrial membrane, resulting in excessive ROS production, decreased ATP generation and PTEN-induced putative kinase 1 accumulation (Lazarou et al., 2015)

ET and WR worked on the data analysis and revisions of the manuscript

These co-localization results demonstrated that cisplatin-induced mitochondrial ROS (mROS) generation is associated with mitochondrial deterioration in HK-2 cells