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Dysregulation of the mitochondrial ACE2/MrgE/NO axis may have a significant effect on the neurodegenerative processes of dopaminergic neurons, where mitochondrial dysfunction and oxidative stress may have a substantial impact [76]

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Additionally, in 2D cultures, ECs can easily spread and migrate due to the lack of physical impediments, while in 3D cultures, a surrounding matrix poses constraints that enforce the ECs adaptation to fit through matrix pores and often require matrix degradation for spreading and migration [240]

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The study design did not have a placebo arm and in a condition such as fibromyalgia, where placebo effects are high, it is difficult to draw any firm conclusions from the results, Professor Littlejohn told Rheumatology Republic