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Phase I trial of triapinecisplatinpaclitaxel chemotherapy for advanced stage or metastatic solid tumor cancers

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[230] developed a GPC3-specific targeted therapy diagnostic NP that modified liposomes (GSI-Lip) with the GPC3-targeting peptide G12, co-loaded with SB and IR780 iodide, to facilitate early detection and precise chemo-photothermal treatment of HCC

Moreover, the infected modeled animals should develop clinical features/morbidity (pathophysiology and clinical manifestations, i.e., signs and symptoms) that resemble human disease and the symptom severity should correlate with the viral load and demographic conditions in human (elderly and immunocompromised subjects are vulnerable to severe disease and mortality)

During the reproductive years, ovaries are palpable, but following menopause, they undergo significant atrophy and shrink considerably