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Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus

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Integration with metabolic therapies: since senescent adipose tissue, liver steatosis and visceral fat contribute to metabolic decline, FOXO4-DRI might improve metabolic resilience

In DDC mice, liver arachidonic acid (AA) concentration (by GC-MS) was increased, and RNA seq/qPCR showed suppression of mitochondrial STAT3 gene targets responsible for fatty acid oxidation and metabolism, all of which was reversed by GW4064