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FIGURE 4 5.1 Plasma protein binding The binding to plasma proteins depends on the physicochemical characteristics of a compound and is typical for a given molecule ( (Table 3)

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A previous study revealed that circulating hypoxic conditions increase ROS production, activate HIF-1, and promote the growth of glioma cells by upregulating the expression of NOX4 mRNA and protein expression in GBM cells ( A study identified that diacylglycerol O-acyltransferase 1 (DGAT1) is highly expressed in HGGs