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This is the single biggest point of failure we see in research efforts outside of major institutional labs

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Likewise, RNA-sequencing analyses in postmortem human studies have yielded evidence of a downregulation of PPP3CA, which encodes for calcium-dependent calmodulin-stimulated protein phosphatase, in patients with CTE compared to healthy subjects, and these patterns were inversely correlated with phosphorylation of tau at Ser202/Thr205 (Seo et al., 2017)