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Although the cytosolic GSTs are dimers, representatives of the microsomal subfamily can be mono-, di-, and trimers, and multienzyme complexes also occur [85, 92]

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Although the downstream response to c-MET is common to many RTKs, the potency, endurance and specificity of c-MET-triggered pathways is secured by a network of upstream signaling co-receptors that physically associate with c-MET at the cell surface (Figure 3) [Trusolino et al