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The ECM provides a scaffold for cell migration and proliferation while also sequestering growth factors and presenting them to cells in a controlled manner

The complete chemical structure of the molecule was determined by Dorothy Hodgkin based on crystallographic data and published in 1955 [147] and 1956, [148] for which, and for other crystallographic analyses, she was awarded the Nobel Prize in Chemistry in 1964

In the breast cancer lung metastasis model, the platelet-derived growth factor C (PDGF-C) level in the microenvironment increases when lung tissue becomes senescent or fibrotic