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Quantification of the fluorescence intensity in each cell region including the nucleus and the cytoplasm was performed using CellProfiler (v4.0.7, CellProfiler Image Analysis Software, RRID:SCR_007358) 54 and QuPath (v0.4.3, Quantitative Pathology & Bioimage Analysis, RRID:SCR_018257) 55

J Cell Mol Med 18:15991611 Guo Q, Guo JB, Yang R, Peng H, Zhao J, Li L et al (2015) Cyclovirobuxine D attenuates doxorubicin-induced cardiomyopathy by suppression of oxidative damage and mitochondrial biogenesis impairment

Introduction Mitochondria play crucial roles in different aspects of cellular physiology, including calcium homeostasis, metabolism, apoptosis and ATP production (Rizzuto et al., c oxidase (COX)), while the gradient of protons is necessary for the ATP synthesis via complex V (ATP synthase

(2022) demonstrated that applying CAP directly to the skin effectively reduced neuropathic pain in patients with diabetic peripheral neuropathy

Diabetes 69(4):784-95 2020 PMC7085253 Braffett BH, Gubitosi-Klug RA, Albers JW, Feldman EL, Martin CL, White NH, Orchard TJ, Lopes-Virella M, Lachin JM, Pop-Busui R, DCCT/EDIC Research Group