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While animal and in vitro studies have examined its activity, large-scale human clinical trials are limited, and its full safety and efficacy profile has not been established

Running wheel activity was continuously measured and plotted in km/day

Irregular sleep-wake rhythm disorder: Involves unpredictable and inconsistent sleep-wake cycles throughout the day

The results show that cagrilintide-semaglutide, co-administered once weekly, results in significantly greater weight loss, with 84 % of participants reaching the target of 5 % body weight loss

8.3 Implications for public health policy The scientific evidence demands immediate and sustained public health action