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While BCAT1s role in regulating macrophage function helps reduce the infiltration of inflammatory factors and has therapeutic potential for various inflammatory diseases (Papathanassiu et al., 2017), it is still unclear whether similar mechanisms exist in the TME

10.1016/S0531-5565(00)00156-X 109 HoyerS.OesterreichK.WagnerO

Furthermore, with respect to dopaminergic signaling, a reduction in anxiety-like behaviors and an increase in locomotor activity in 3xTg mice are accompanied by an increase in postsynaptic D2 dopamine receptors in the striatum and in D2-autoreceptors in substantia nigra/VTA cell bodies (Gloria et al., 2021)

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