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The roles of lipid and glucose metabolism in modulation of -amyloid, tau, and neurodegeneration in the pathogenesis of Alzheimer disease

The mRNA levels of GCLC and GS were both lower (50% and 30%, respectively) while mRNA levels of GCLM were unchanged

Fahey MC, Cremer PD, Aw ST, Millist L, Todd MJ, White OB, Halmagyi M, Corben LA, Collins V, Churchyard AJ, Tan K, Kowal L, Delatycki MB

The results demonstrated that these nanocarriers possess characteristics enabling them to access the brain, and they are at least as effective as the corresponding free drugs in protecting against rotenone-induced reduction in cell viability, increased iron content, and oxidative stress

This can result in the removal of an activation peptide and exposes a new N-terminus in the catalytic domain starting with Ile16