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On the other hand, in pathological conditions such as early diabetic nephropathy, inappropriate upregulation of SQOR leads to excessive consumption of signaling H 2 S, resulting in insufficient H 2 S signaling and exacerbated tissue damage ( 2 S, but to maintain H 2 S concentrations within an optimal steady-state windowand when this balance is lost in either direction, opposite pathological consequences ensue

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Their crucial contribution was demonstrating the superior sensitizing effect of copper-based materials: CuO NPs (8020 nm) combined with 1 mM ascorbate reduced IC 5 0 values to 0.010.37 g/mL, achieving sensitization factors of 121620-fold, effective even against drug-resistant cell lines