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The impairment in the mitochondrial respiratory chain can promote ROS over-production and accumulation, leading to oxidative stress, phospholipid peroxidation, and ultimately ferroptosis [13, 14]

The pale yellow keratin of non-pigmented hair appears white due to light refraction or reflection.34 Compared with pigmented hair, gray hair is thicker, stiffer, and more difficult to manage, grows faster, and is more susceptible to UV radiation damage, requiring greater protection.35 Alterations in hair fiber make it more difficult to maintain artificial color, leading many individuals to undergo repeated dyeing procedures, which may result in toxicity from artificial hair dyes.36 There are no sex-related differences in the prevalence of premature graying.37 In women, gray hair usually begins along the hairline, whereas in men it typically starts in the temporal region and sideburns

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10.1186/s12876-021-01977-1 BMC Gastroenterol

Proteins such as super oxide dismutase 1 and growth hormone have persulfurated cysteine residues in their structures 31,32,33,34