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For example, PARP1 binds a DNA single strand break, then utilizes NAD + to ADP-ribosylate macromolecules in the vicinity, a signal for recruitment of DNA repair machinery 6

Oestrogens, such as oestradiol, are thought to be important in maintaining bone mass in women, and are thought to act by inhibiting paracrine factors that promote bone resorption (see below)

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