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Metabolic Flux Analysis further substantiated the importance of the cellular energetic state for the biotransformation [105]

Brain 139 , 723737 (2016)

Mechanistically, these effects involve interconnected pathways: mitochondrial dysfunction, neuroinflammation, disrupted glutamate-glutamine cycling, osmotic imbalance, impaired glutamatergic signaling, and dysregulated cerebrovascular autoregulation (Oja et al