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Park H-J, Furmaga H, Cooperrider J, Gale JT, Baker KB, Machado AG

We are highlighting amylin as the hottest new mechanism for obesity, Leerink Partners analysts wrote in a Tuesday note to investors, explaining that amylin mostly works as a satiety signal and affects hedonic aspects of eating. The molecule acts on several regions of the brain to lower the feeling of being rewarded after eating

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10.1038/35004513 Nature 79 KimI

This mechanism has direct relevance for post-surgical recovery, crush injuries, and any condition where vascular compromise threatens tissue viability