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Description

Drugs RD 2014, 14, 2529

doi: 10.1016/j.abb.2015.08.008

Aquacobalamin (H 2 OCbl) brominated at the C10-position of the corrin reacts with GSH to give Cbl(II) via GSH complexation and subsequent reaction of this complex with a second GSH molecule, whereas unmodified H 2 OCbl generates glutathionyl-Cbl, which is resistant to further reduction by GSH