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S.et al (2016)

Proc Natl Acad Sci USA 105(31):1092510930

[DOI] [PubMed] [Google Scholar] [71].Ishihara T, Kohno H, Ishihara N

Gene variants and polymorphisms The study of pharmacogenomics in recent decades has proved that genetic polymorphism of drug-metabolizing enzymes is an important mediating factor in determining individual drug responses

Sorafenib stimulates NRF2 expression in HCC cells, which boosts MT-1G expression, which prevents ferroptosis by inhibiting GSH depletion, which is one of the pathways associated in sorafenib resistance (87)