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To date, there is still no effective treatment for ALS, and the two currently available drugs, riluzole and edaravone, only extend survival of ALS patients by few months [78,79,80,81,82,83]

The use of the TCM formulas should be based on the treatment with syndrome differentiation, which is one of the features of TCM theoretical system

Vitamin B12 deficiency can occur due to many reasons, mainly improper diet or you have a condition where your body cant absorb as much

In this protective role, ATF4 drives the expression of the chaperone heat shock protein family A (Hsp70) member 5 (HSPA5), which in turn stabilizes and enhances the activity of GPX4, thereby inhibiting ferroptotic cell death ( In ferroptosis resistant melanoma cells, CHAC1 was shown to be upregulated by NRF2 independent from ER stress signaling alongside the Aldo-Keto Reductase Family 1 Member C1 (AKR1C1) capable of degrading lipid radicals ( CHAC1 , most melanoma cell lines appear to be resistant against ferroptosis

Nat Rev Mol Cell Biol 23(10):663679