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Here, we used the existing pre-clinical models of severe and moderate COVID-19 to evaluate the efficacy of a Spike-based DNA vaccine (pCTV-WS) for protection against different VOCs

2.2.2 The gutheart axis The gutheart axis is an emerging concept describing bidirectional communication between the gastrointestinal tract and the cardiovascular system via metabolic, inflammatory, and immune pathways [23]

Lactobacillus plantarum is known for its positive impact on health, including immunomodulatory functions, maintenance of intestinal flora balance, promotion of nutrient absorption, alleviation of lactose intolerance, and inhibition of tumor cell formation