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Alterations in major signaling pathways TGF signaling In general, tumors co-opt TGF signaling to induce metastasis and chemoresistance through promoting angiogenesis, EMT, increased GSH production, a stem cell phenotype, ECM remodeling, and immune escape [90]

FIGURE 1 2 Retrieval methods The literature review was conducted using several databases, including Web of Science ( ScienceDirect (www.sciencedirect.com), and PubMed ( The search keywords included pomegranate peel extract, Punica granatum L., bioactivity, hydrogels, nanodrugs, tissue engineering, biomedical materials, and their combinations

Conversely, endogenous defense mechanisms for endothelial homeostasis are also severely hit

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Once reconstituted with bacteriostatic water, store refrigerated and use within 2 to 4 weeks