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Tkaczyk et al

A Strategy for Cancer Prevention: Stimulation of the Nrf2-ARE Signaling Pathway

4 Cells with high levels of missense heteroplasmy have a growth disadvantage in standard cell culture conditions

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sensitization 8.4 Long-term exposure 8.4.1 Oral 8.4.2 Inhalation 8.5 Reproductive and developmental toxicity 8.6 Mutagenicity and related end-points 8.6.1 Bacteria 8.6.2 Non-mammalian eukaryotic systems 8.6.2.1 Gene mutation assays 8.6.2.2 Chromosome alterations 8.6.3 Cultured mammalian cells 8.6.3.1 Gene mutation assays 8.6.3.2 Chromosome alterations and sister chromatid exchange 8.6.4 In vivo assays 8.6.4.1 Somatic cells 8.6.4.2 Germ cells 8.6.5 Other assays 8.6.5.1 DNA single-strand breaks 8.6.5.2 DNA cross-linking 8.6.6 Cell transformation 8.7 Carcinogenicity bioassays 8.7.1 Inhalation exposure 8.7.2 Co-carcinogenicity and promotion studies 8.8 Neurological effects 8.9 Immunological effects 8.9.1 Direct effects on immune cells 8.9.2 Generation of antibodies reacting with acetaldehyde-modified proteins 8.9.3 Related immunological effects 8.10 Biochemical effects 9