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Thresholds based on cluster size, estimated R 2 , and the number of nested CGs were applied to highlight regions most consistently supported across independent studies, following general M-QTL practices 86,87

Hamelet J, Demuth K, Dairou J, Ledru A, Paul JL, Dupret JM, Delabar JM, Rodrigues-Lima F, Janel N: Effects of catechin on homocysteine metabolism in hyperhomocysteinemic mice

Cells cultured in the above normal cell culture conditions were used as normoxia control

High-level TGF signalling is characteristic of many stroma-rich tumour types, including CMS4 CRC [3] and is a major metastasis-promoting signalling pathway in late-stage CRC [45]

In this review, we summarize the effective role of flavonoids in the treatment of liver disease (in Figure 3), and provide insights into their mechanism of action and targets