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A reducing course of benzodiazepines is well established as a mainstay of therapy to mitigate features of withdrawal, with a suggestion that symptom-triggered administration (ie, using CIWA-Ar scoring) provides more effective management as compared to fixed schedule administration

[PubMed] [Google Scholar][81] Avci R, Inan U, Kaderli B

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Macrophages exhibit a heterogeneous and plastic phenotype, capable of polarizing into the pro-inflammatory M1 or the reparative and anti-inflammatory M2 phenotypes