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Free Radic Biol Med 23:148154

Mentlein, R

Due to the Complexity of FD diagnosis and treatment, there remains a scarcity of high-quality clinical studies pertaining to FD, which further restricts research into the exact role of PPIs in FD

41 We evaluated the expression of these proteins in our cell lines and found that under cystine starvation, AsPC1 control cells increase xCT to a greater extent than PKM2KO cells, while Panc1 control and PKM2KO cells have similar expression (Figs

Another challenge lies in the reliance on animal models in experiments, as these models differ significantly from humans in genetic background and disease heterogeneity, and there is still a lack of result validation in human patients