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Similar content being viewed by others Introduction Long non-coding RNAs Although 70% of the genome is transcribed into RNA, only 2% is translated into proteins, the remaining transcripts being either short or long noncoding (nc) RNAs [1]

10.1016/j.scitotenv.2021.145906 53 ZietzschmannF.SttzerC.JekelM

Other Nrf2-dependent genes, including GPX4, GSH and NADPH synthesis genes, as well as epigenetic regulators of lipid hydroperoxides, contribute to its ferroptosis-inhibitory effects (117119)

For instance, early oxidative stress may primarily induce mitochondrial damage and ferroptosis, subsequently triggering compensatory activation of mitophagy (Xu G

This imbalance sustains a self-amplifying loop of oxidative stress, neuroinflammation, and mitochondrial dysfunction, reinforcing chronic pain pathophysiology