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Description

Alpha-lipoic acid (ALA) is an intracellular redox regulator that reduces OxS, blocks activation of NF-kB and lowers both ADAM17 activity and ACE2 upregulation 529

Studies showed that the expression levels of HK2, pyruvate kinase type M2 (PKM2), and Lactate dehydrogenase A (LDHA) in synovial tissues of RA patients were 35 times higher than those of the healthy population