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Yet, the precise spatiotemporal causal sequence among these three elements remains unconfirmed by longitudinal human studies

also found that the occurrence of cuproptosis was significantly related to mitochondrial metabolism, providing a more plausible mechanism for explaining the anti-cancer effect of ES depending on the transport of extracellular copper ions and the mitochondrial respiration intensity of cancer cells (13)

Clin Adv Hematol Oncol 18(12):791-792, 2020

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Additionally, white adipose tissue produces an excess of aromatase, which is responsible for converting androgenic hormones into estrogen, further elevating its plasma concentrations