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They also demonstrated that Fer-1 mitigates not only rotenone-induced apoptosis but also synuclein aggregation and ER stress

10.1093/hmg/ddae154 267 WangY.FengY.LiM.YangM.ShiG.XuanZ.et al (2022a)

The mechanism behind these effects involves upregulating LDL receptor expression and inhibiting the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), critical for cholesterol synthesis (Qin et al., 2017)

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In summary, we established an assay for the direct and continuous monitoring of a glutaredoxin-dependent deglutathionylation reaction using roGFP2(SSG) monothiol variants as model substrates