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True addiction (compulsive use, craving, rewardseeking) is uncommon with SSRIs

Facial flushing is more common in women, especially with triamcinolone, and settles on its own (an antihistamine helps)

For individuals with Wilson's disease (a genetic disorder causing copper accumulation) or other copper metabolism disorders, theoretical caution is warranted, though even in these populations topical GHK-Cu is unlikely to pose significant risk given the minimal systemic absorption

ESI was introduced in 1989 by John B

Jang H-S, Noh MR, Kim J, Padanilam BJ (2020) Defective mitochondrial fatty acid oxidation and lipotoxicity in kidney diseases