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Dexrazoxane is a cyclic derivative of EDTA that easily penetrates the cell membrane and forms a ring-opening iron chelator

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doi: 10.1016/j.it.2016.01.002 86 JiangYHuZHuangRHoKWangPKangJ

Japans PMDA and Indias 2019 guidelines lack nanomaterial-specific thresholds, and regulatory divergence often classifies similar products as drugs or devices, impeding harmonized safety standards [297, 298]

It takes approximately 4 to 5 weeks for the drug to reach a steady level in the body, and total effects may not be apparent for at least two months after treatment begins