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Description

Under basal conditions, the expression of Nrf2 remains low due to the proteasomal degradation mediated by the Cul3/Rbx1 E3 ubiquitin ligase

Clinical response correlates strongly with early intervention

We compared it to the typically used single-photon avalanche diode (SPAD) detector

Specifically, the expression of ACSL4 is elevated in ferroptosis-sensitive cells compared with that in ferroptosis-resistance cells, and patients who have complete or partial responses to sorafenib have higher liver ACSL4 expression than those who have a poor response to sorafenib [99, 100]