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Sphingomyelin accumulation in liver, lungs, and other tissues leads to hepatosplenomegaly, pulmonary disease, liver dysfunction, and dyslipidemia in most patients

Proc Natl Acad Sci USA.1984;81:9359

The PI3K/Akt/GSK-3/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility

10.3390/ijms20040859 21 KawagishiH.ShimadaA.ShiraiR.OkamotoK.OjimaF.SakamotoH.et al (1994)

For further investigation, we systematically examined the protective effect induced by CBS on HK-2 cells against a series of soft metal compounds (including anticancer drugs such as carboplatin and arsenic trioxide and common heavy metal pollutants such as cadmium and mercury), hard metal compounds, and oxidant