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The rapid increase in B cell responses in the combination group raised concerns about whether regulatory B cells (Bregs) also increased rapidly, as Bregs can effectively inhibit effector CD4 + T generation and maintain their function 27

The main barriers at this stage are the lack of standardized laboratory assays and the high cost and limited availability of advanced imaging

Accordingly, this information suggests that atorvastatin may work as a suppressor of inflammatory T helper-1 and -17 reactions, downregulating co-stimulatory molecules and concentration of Tregs