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The core problem with looking for cytokines in peripheral blood is that cytokines generally do not function as endocrine signalers, but are rather normally autocrine and paracrine signalers (see Box 1)

10.1016/j.envpol.2010.03.003 84 KannegantiV.GuptaA

We also discussed how the onco-virus EBV fights with the host by utilizing host ubiquitin signaling or even encoding v-DUB to hijack host cellular processes