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Tretinoin (retinoic acid) is a prescription-strength vitamin A derivative with more than four decades of randomized controlled trial data behind it

Physiol Rev 94(2):329354 Nishinaka Y, Masutani H, Nakamura H, Yodoi J (2001) Regulatory roles of thioredoxin in oxidative stress-induced cellular responses

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In addition, DNA response elements can exert an allosteric effect on transcription regulators, so that the regulator can activate transcription in the context of one gene, but repress transcription in another gene