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Buxton GV, Wood ND, Dyster S (1988) Ionisation constants of .OH and HO2

ROS can induce mutations in the BRCA1 gene, which is involved in DNA repair, leading to impaired DNA damage response and increased susceptibility to tumorigenesis [100]

Furthermore, BHB suppresses endoplasmic reticulum stress and attenuates insulin/insulin-like growth factor (IGF-1) signaling, thereby enhancing stress resistance [58, 59]

Lactate, produced primarily by astrocytes via aerobic glycolysis, serves as a key metabolic substrate for neurons during periods of high synaptic activity or metabolic stress [24, 43]