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This dual-enzyme cascade is widely present in the cytoplasm and is highly sensitive to oxidative stress

doi:10.1093/gerona/glp194 Luo M, Fernandez-Estivariz C, Jones DP, Accardi CR, Alteheld B, Bazargan N, Hao L, Griffith DP, Blumberg JB, Galloway JR, Ziegler TR (2008) Depletion of plasma antioxidants in surgical intensive care unit patients requiring parenteral feeding: effects of parenteral nutrition with or without alanyl-glutamine dipeptide supplementation

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Unlike previous models, CFAX12 uniquely allows periodic TER measurements, providing a reproducible, non-invasive assessment of barrier integrity over time, a critical endpoint for inhalation toxicity studies