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Furthermore, the hydrogen bond, which involves the conserved residue Asn419 hTrxR1 , is also present in structures of rat TrxR and TGR with a reduced C-terminal end

Severe vitamin B12 deficiency affects about 3 percent of adults in developed countries, but a more marginal deficiency may impact 26 percent, with the highest rates among adults older than 60

Data also suggest that it is important to consider environmental factors that have arisen coincident with the current epidemic of metabolic dysfunction as potential modifiers of redox or ROS and purveyors of possible misinformation and inappropriate adaptation

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PMID 20981001