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Briefly, 1 cm small intestines were incised lengthwise, chopped into pieces, and thoroughly washed with cold PBS

These regenerative benefits are backed by emerging clinical data

In microglia, butyric acid also activates the GPR109A-mediated signaling pathway to downregulate the NF-B signaling pathway, inhibits the production of pro-inflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) and pro-inflammatory cytokines (TNF-, IL-1, and IL-6) in microglia, and prevents the onset and progression of neuroinflammation

Gastrointestinal protection: Consistent with its origins in gastric juice protein, BPC-157 has demonstrated protective and healing effects on gastrointestinal mucosa, including in models of inflammatory bowel disease, ulcers, and esophageal damage (5)