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Studies looking at gene expression of macrophages in pathologic conditions have demonstrated heterogenous activation and functionality as well as significant overlap in gene expression whether stimulated with LPS or IL-10 (138140)

Other non-limiting examples of types of cancers suitable for use in the methods encompassed by the present invention include human sarcomas and carcinomas such as fibrosarcoma, myxosarcoma, liposarcoma, chondrosarcoma, osteogenic sarcoma, chordoma, angiosarcoma, endotheliosarcoma, lymphangiosarcoma, lymphangioendotheliosarcoma, synovioma, mesothelioma, Ewing's tumor (Ewing's tumor), leiomyosarcoma, rhabdomyosarcoma, squamous cell carcinoma, basal cell carcinoma, adenocarcinoma, sweat gland carcinoma, sebaceous gland carcinoma, papillary adenocarcinoma, cystadenocarcinoma, medullary carcinoma, bronchial carcinoma, renal cell carcinoma, hepatoma, cholangiocarcinoma, choriocarcinoma, seminoma, embryonal carcinoma, Wilms ' tumor, bone carcinoma, brain tumor, lung cancer (including lung adenocarcinoma), small cell lung cancer, bladder cancer, epithelial cancer, glioma, astrocytoma, and sarcoma, Medulloblastoma, craniopharyngioma, ependymoma, pinealoma, hemangioblastoma, acoustic neuroma, oligodendritic glioma, meningioma, melanoma, neuroblastoma, retinoblastoma

The optimum activity for rSmGST was found to be pH 6.5 and 25C

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