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Studies have demonstrated that FOXO4-DRI modulates multiple regulatory pathways, including insulin signaling, cell cycle control, and oxidative stress response

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Nevertheless, it is well appreciated that astrocytes play a central role in brain metabolic homeostasis, particularly concerning brain energetics and redox balance

J Sleep Res 8(1):5764 Leger D, Laudon M, Zisapel N (2004) Nocturnal 6-sulfatoxymelatonin excretion in insomnia and its relation to the response to melatonin replacement therapy