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Phytotherapy Research, 35 (1), 20-32

Mechanism by which heparin proteoglycan modulates mast cell chymase activity

Pricop, L

In a Complete Response Letter, the regulator stated that Aldeyras New Drug Application did not demonstrate efficacy in treating ocular symptoms associated with dry eyes and informed the company that at least one additional adequate and well-controlled study would be required to demonstrate efficacy