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Inhibition of COX-2 by NSAIDs blocks PG production at sites of inflammation, whereas inhibition of COX-1 in other tissues (platelets and the gastroduodenal mucosa) leads to common adverse effects of NSAIDs, such as bleeding and gastrointestinal ulceration ( Owing to the adverse effects of NSAIDs and corticosteroids, disease-modifying antirheumatic drugs (DMARDs), a class of immunosuppressive and immunomodulatory agents, are developed to prevent and relieve RA aggression

Neuron 18(5):691696 Stomberski CT, Hess DT, Stamler JS (2019) Protein S-nitrosylation: determinants of specificity and enzymatic regulation of S-nitrosothiol-based signaling

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