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GM-CSF granulocytemacrophage colony-stimulating factor, RhBMP recombinant human bone morphometric proteins, PTH 134 parathyroid hormone 134, IGFBP-3 recombinant human IGF binding protein-3, IGF-1 insulin-like growth factor-1, HGF hepatocyte growth factor, RhPDGF-BB recombinant human platelet-derived growth factor-BB, FGF-1 fibroblast growth factor-1, NGF nerve growth Factor, RhEGF recombinant human epidermal growth factor, RhGDF-5 recombinant human growth differentiation factor-5 Bone tissue repair While bone tissue possesses a self-healing capacity, critical defects or fractures resulting from trauma or surgical resection are difficult to repair autonomously, particularly in patients with metabolic diseases such as osteoporosis and diabetes

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In the absence of stomach and gastric acid, the damaging effects of cysteamine (400 mg/kg s.c., sacrifice 24 hours thereafter), so far thought to be an acid related duodenal ulcerogen, and the cytoprotective effects of NaBPC157 (10 g or 10 ng/kg i.p.) were further challenged in comparison with reference agents (cimetidine (50), ranitidine (10), omeprazole (10), bromocriptine (10) and atropine (10) (values given in mg/kg i.p., 1 hour before cysteamine)) known also to be cytoprotective

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