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CHAC1 degrades GSH, leading to GSH depletion and oxidative stress

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Neuro Endocrinol Lett 32:13340, PMID: 21552194 Kaddurah-Daouk R, Yuan P, Boyle SH, Matson W, Wang Z, Zeng ZB, Zhu H, Dougherty GG, Yao JK, Chen G, Guitart X, Carlson PJ, Neumeister A, Zarate C, Krishnan RR, Manji HK, Drevets W (2012) Cerebrospinal fluid metabolome in mood disorders-remission state has a unique metabolic profile