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Common causes include hormonal changes, polycystic ovary syndrome (PCOS), the use of birth control pills, and thyroid dysfunction

& Scheller, E

10.1073/pnas.96.13.7324

It is not meant for self-administration at home

6, 7 Because all newborn screening programs in the United States and many other countries worldwide include biotinidase deficiency in their panel of screened conditions, there is an increased need to define and standardize laboratory approaches for enzymatic biotinidase testing, to delineate situations for which follow-up molecular testing is warranted, and to characterize variables that can influence test performance and interpretation of results